When everyone is on drugs, are the drug-free going to be disadvantaged?

An interesting thought I have been thinking about with how much drug use (medical, nor recreational) is being hoisted upon the populace is this: at some point in the near future will the hyper-medicated essentially be at an advantage over the drug-free?

To be clear, I am NOT talking about conventional ‘recreational’ drugs like mushrooms, pot etc that at least overtly appear to do nothing but have deleterious effects on the person.  I am referring more to people not being able to feel pain, tranqulizing their depression away, or even more directly things like ritalin and other ADD meds that give near super-human focus to the user.

It pissed me off in college where kids on the ADD meds could sit there and study intently for hours on end.  There was a good drug trade at the time, I think a single pill went for 5-10$, probably even more now, but people would swear by them ‘studying was just so interesting man’.

Regardless, what happens to those people who dont feel pain, have hyper-focus, etc compared to the ‘normie/drug free’ of us?

Related is an anime called sword of the stranger where the main guy (and the main bad guy) are the only ones who dont take a drug that prevents the feeling of pain, pretty redpilled overall.